THPO Polyclonal Antibody for Human(Homo sapiens) | EIAab.comTHPO Polyclonal Antibody for Human(Homo sapiens)

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Index > Protein center > THPO(Gene name) > Human

THPO (Gene name),

Thrombopoietin (Protein name ), TPO_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

THPO(MGDF);

Protein name:

Thrombopoietin;

Alternative:

Megakaryocyte colony-stimulating factor;C-mpl ligand(ML);Myeloproliferative leukemia virus oncogene ligand;Megakaryocyte growth and development factor(MGDF);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.

Subcellular Location:

Secreted

Protein Attributes:

Sequence length:

353

Sequence:

50:

100:

150:

200:

250:

300:

350:

353:

QEG

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF00758

UniGene:

Hs.1166

MIM:

187950

KEGG:

hsa:7066

STRING:

9606.ENSP00000204615

SMR:

P40225

String:

P40225

Uniprot:

P40225

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ELISA Kit for Human Thrombopoietin

Cat.:

E0135r

Price:

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Manual:

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Packing:

96T

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ELISA Kit for Human Thrombopoietin

Cat.:

E0135h

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Packing:

96T

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ELISA Kit for Human Thrombopoietin

Cat.:

E0135m

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96T

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ELISA Kit for Human Thrombopoietin

Cat.:

E0135d

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96T

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ELISA Kit for Human Thrombopoietin

Cat.:

E0135p

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Packing:

96T

CLIA Kit for Human Thrombopoietin

Cat.:

U0135p

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MSDS:

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Packing:

96T

CLIA Kit for Human Thrombopoietin

Cat.:

U0135d

Price:

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Manual:

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Packing:

96T

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CLIA Kit for Human Thrombopoietin

Cat.:

U0135h

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Human Thrombopoietin

Cat.:

U0135r

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Human Thrombopoietin

Cat.:

U0135m

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Thrombopoietin

Cat.:

P0135Rb-r

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Thrombopoietin

Cat.:

P0135Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Thrombopoietin

Cat.:

P0135Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Thrombopoietin

Protein for Human Thrombopoietin

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand."
de Sauvage F.J. , Hass P.E. , Spencer S.D. , Malloy B.E. , Gurney A.L. , Spencer S.A. , Darbonne W.C. , Henzel W.J. , Wong S.C. , Kuang W.-J. , Oles K.J. , Hultgren B. , Solberg L.A. Jr. , Goeddel D.V. , Eaton D.L.
Nature369:533-538(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Fetal liver.
2.

"Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl."
Bartley T.D. , Bogenberger J. , Hunt P. , Li Y.-S. , Lu H.S. , Martin F. , Chang M.-S. , Samal B.B. , Nichol J.L. , Swift S. , Johnson M.J. , Hsu R.-Y. , Parker V.P. , Suggs S. , Skrine J.D. , Merewether L.A. , Clogson C. , Hsu E. , more...
Cell77:1117-1124(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Fetal liver.
3.

"Human thrombopoietin: gene structure, cDNA sequence, expression, and chromosomal localization."
Foster D.C. , Sprecher C.A. , Grant F.J. , Kramer J.M. , Kuijper J.L. , Holly R.D. , Whitmore T.E. , Heipel M.D. , Bell L.A.N. , Ching A.F. , McGrane V. , Hart C. , O'Hara P.J. , Lok S.
Proc. Natl. Acad. Sci. U.S.A.91:13023-13027(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1)
4.

"Molecular cloning and chromosomal localization of the human thrombopoietin gene."
Sohma Y. , Akahori H. , Seki N. , Hori T.-A. , Ogami K. , Kawamura K. , Miyazaki H.
FEBS Lett.353:57-61(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)
5.

"Genomic structure, chromosomal localization, and conserved alternative splice forms of thrombopoietin."
Gurney A.L. , Kuang W.-J. , Xie M.-H. , Malloy B.E. , Eaton D.L. , de Sauvage F.J.
Blood85:981-988(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 2)
6.

"Purification and characterization of thrombopoietin."
Kato T. , Ogami K. , Shimada Y. , Iwamatsu A. , Sohma Y. , Akahori H. , Horie K. , Kokubo A. , Kudo Y. , Maeda E. , Kobayashi K. , Ohashi H. , Ozawa T. , Inoue H. , Kawamura K. , Miyazaki H.
J. Biochem.118:229-236(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Liver.
7.

"Cloning and characterization of the human megakaryocyte growth and development factor (MGDF) gene."
Chang M. , McNinch J. , Basu R. , Shutter J. , Hsu R. , Perkins C. , Mar V. , Suggs S. , Welcher A. , Li L. , Lu H. , Bartley T. , Hunt P. , Martin F. , Samal B. , Bogenberger J.
J. Biol. Chem.270:511-514(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)
tissue: Placenta.
8.

"Cloning and sequencing of human thrombopoietin."
Im S.H. , Lee W.S. , Chung K.H.
Submitted (1996-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 3)
9.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue: Brain.
tissue: Testis.
10.

"An activating splice donor mutation in the thrombopoietin gene causes hereditary thrombocythaemia."
Wiestner A. , Schlemper R.J. , van der Maas A.P.C. , Skoda R.C.
Nat. Genet.18:49-52(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISEASE
11.

"Peptide, disulfide, and glycosylation mapping of recombinant human thrombopoietin from ser1 to Arg246."
Hoffman R.C. , Andersen H. , Walker K. , Krakover J.D. , Patel S. , Stamm M.R. , Osborn S.G.
Biochemistry35:14849-14861(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISULFIDE BONDS;GLYCOSYLATION AT SER-22; THR-58; THR-131; THR-179; THR-180; SER-184; ASN-197; ASN-206; THR-213; ASN-234; ASN-255 AND SER-265
12.

"Structure of the receptor-binding domain of human thrombopoietin determined by complexation with a neutralizing antibody fragment."
Feese M.D. , Tamada T. , Kato Y. , Maeda Y. , Hirose M. , Matsukura Y. , Shigematsu H. , Muto T. , Matsumoto A. , Watarai H. , Ogami K. , Tahara T. , Kato T. , Miyazaki H. , Kuroki R.
Proc. Natl. Acad. Sci. U.S.A.101:1816-1821(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.51 ANGSTROMS) OF 22-184 IN COMPLEX WITH ANTIBODY;DISULFIDE BONDS

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